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折扣/货期| 货号：SIH-614-1MG | 规格：1 mg | 目录价：￥2376 |
产品详情
产品名称:
Verrucarin A
别名:
Muconomycin-A; 379-Y; Glutinosin-I; Myrothecin-I; NSC-126728
产品描述:
Modulates Amyloid-beta production in Alzheimer’s neurons
保存温度:
-20ºC
运输温度:
Shipped Ambient
预期分子量:
502.6
产地:
加拿大
功能与背景:
Verrucarin A is a macrocyclic trichothecene mycotoxin from Myrothecium sp. It is being investigated as it modulates amyloid-beta production in Alzheimer's patients neurons (1). It is a potent and selective inhibitor of the steroid receptor coactivator-3 and selectively down-regulates its expression (2). It is cytotoxic to multiple types of cancer cells at low nM concentrations (IC50=4.9 nM for HepG2 cells) but not toward normal liver cells (2,3). It enhances TNFα-induced (4) and TRAIL-induced apoptosis (5). It reduces phosphorylation of IREα and inhibits tunicamycin-induced ER stress in FaO rat liver cells (6).
纯度:
>98% (HPLC); NMR (Conforms)
来源:
Synthetic
CAS号:
3148-09-2
分子式:
C27H34O9
溶解度:
May be dissolved in DMSO (25 mg/ml)
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