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折扣/货期| 货号：CDX-O0144-M100 | 规格：100 mg | 目录价：￥1414 |
| 货号：CDX-O0144-G001 | 规格：1 g | 目录价：￥6202 |
产品详情
产品名称:
Olaparib
别名:
AZD 2281; Ku-0059436; Lynparza; 1-(Cyclopropylcarbonyl)-4-[5-[(3,4-dihydro-4-oxo-1-phthalazinyl)methyl]-2-fluorobenzoyl]piperazine
产品描述:
Olaparib is a cell-permable potent inhibitor of PARP1 and PARP2 (IC50=5 and 1nM, respectively) but is less effective against the PARP tankyrase-1 (IC50=1.5µM). Some poly(ADP-ribose) polymerases (PARPs) assist in the repair of single-strand DNA nicks, an important step in base excision repair (BER), counteracting against DNA alkylating agents. Olaparib is a anticancer and chemotherapeutic agent (especially in cancers with BRCA mutations) that can be used in cells and in animals, alone or in combination therapy with alkylating agents, to block BER and increase cancer cell death.
宿主来源:
Synthetic
保存温度:
-20°C
运输温度:
Ambient
预期分子量:
434.47
产品形式:
solid
有效期:
Stable for at least 2 years after receipt when stored at -20°C.
产地:
瑞士
纯度:
>98% (HPLC)
CAS号:
763113-22-0
分子式:
C24H23FN4O3
溶解度:
Soluble in DMSO (20mg/ml) or DMF (10mg/ml). Slightly soluble in ethanol (1mg/ml).
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