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折扣/货期| 货号：CDX-A0271-M250 | 规格：250 mg | 目录价：￥798 |
| 货号：CDX-A0271-G001 | 规格：1 g | 目录价：￥2576 |
产品详情
产品名称:
5-Azacytidine
别名:
5-Azacitidine; Antibiotic U18496; 5-AzaC; Ladakamycin; Mylosar; NSC102816; NSC103-627; U18496; WR183027
产品描述:
5-Azacytidine, a chemical analogue of the DNA and RNA nucleoside cytidine, is an cell permeable inhibitor of DNA methyltransferases, potentially serving to reverse epigenetic changes. It reduces hypermethylation associated with certain diseases, including myelodysplastic syndromes (IC50s = 2.4 and 2.6µM for in vitro anti-myeloma activity) and cancer (IC50s ~ 0.4µM for inhibiting proliferation of various cancer cell lines). It has a reported half-life of 17 hours and is considerably cytotoxic; it must be incorporated into DNA to covalently trap DNA methyltransferases. Induces demethylation and reactivation of silenced genes. Improves the efficiency of reprogramming of stem cells; induces differentiation of mesenchymal stem cells into cardiomyocytes.
宿主来源:
Synthetic.
保存温度:
-20°C
运输温度:
Ambient
预期分子量:
244.2
产品形式:
solid
有效期:
Stable for at least 2 years after receipt when stored at -20°C.
产地:
瑞士
纯度:
>98% (HPLC)
CAS号:
320-67-2
分子式:
C8H12N4O5
溶解度:
Soluble in ethanol, DMSO, DMF (30mg/ml), water or PBS (10mg/ml).
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