官网链接
折扣/货期| 货号：CDX-T0461-M005 | 规格：5 mg | 目录价：￥826 |
| 货号：CDX-T0461-M025 | 规格：25 mg | 目录价：￥3346 |
产品详情
产品名称:
Tofacitinib citrate
别名:
CP-690550; Xeljanz; Tasocitinib; (3R,4R)-4-Methyl-3-(methyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-beta-oxo-1-piperidinepropanenitrile citrate salt
产品描述:
Tofacitinib citrate is a potent cell permeable JAK3 inhibitor (IC50=1nM), which Shows also JAK-1 inhibitory activity. This is an immunosuppressive and anti-inflammatory agent. It inhibits signaling through heterodimeric receptors associated with JAK3, JAK1, or both of them, with functional selectivity over JAK2-paired receptors. Blocks downstream STAT signaling, resulting in potent inhibition of several cytokines, including interleukins 2, 4, 7, 9, 15 and 21, which are integral to lymphocyte activation, function and proliferation. It also has been shown to be a potent and selective inhibitor of HIV-1 replication and virus reactivation in vitro. It is investigated against the spread of the SARS-CoV-2 (COVID-19).
宿主来源:
Synthetic
保存温度:
+20°C
运输温度:
Ambient
预期分子量:
312.4 . 192.1
产品形式:
solid
有效期:
Stable for at least 2 years after receipt when stored at RT.
产地:
瑞士
纯度:
>98% (HPLC)
CAS号:
540737-29-9
分子式:
C16H20N6O . C6H8O7
溶解度:
Soluble in DMSO (20mg/ml) or DMF (5 mg/ml). Slightly soluble in ethanol.
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