NCOR2/SMRT (human recombinant)-其他重组蛋白-ELISA_抗体_蛋白_核苷酸

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NCOR2/SMRT (human recombinant)

品牌：Cayman

官网链接

说明书

折扣/货期

货号：11633

规格：50 µg

目录价：￥8316

产品详情

产品名称:

NCOR2/SMRT (human recombinant)

别名:

产品描述:

Nuclear receptor corepressor 2 (NcoR2) is a transcriptional corepressor that plays an essential role in the regulation of development and metabolism. Histone deacetylases (HDACs) can mediate nuclear receptor functions by forming co-repressor complexes with nuclear receptors in the absence of ligands. However, HDACs are primarily responsible for catalyzing the deacetylation of core histones. HDAC3, a class I HDAC related to the yeast HDAC Rpd, is inactive alone and requires binding with the deacetylase activation domain (DAD) of NcoR2 for activation.{14468} The deacetylation of core histones by HDACs results in the tightening of nucleosomal integrity, restriction of access to transcription factors, and the suppression of gene transcription. In addition, HDACs mediate other transcription regulatory pathways by associating with transcription factors, such as E2F, TFIIE, TFIIF, NF-κB, p300, Stat3, p53, and the retinoblastoma (Rb) protein.{14467} The modification of chromatin structure and other non-histone proteins by HDACs serves to control many complex biological events, including cell development, differentiation, programmed cell death, angiogenesis, and inflammation. Thus, dysregulation of HDACs, leading to an imbalance of acetylation and deacetylation, may be involved in the pathogenesis of various diseases, including cancer and inflammatory diseases.{14468}

保存温度:

-80

运输温度:

-80

产品形式:

50 mM Tris-HCl, pH 8.0, with 138 mM sodium chloride, 20 mM glutathione, and 10% glycerol

有效期:

180

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