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Interleukin-6 (human, recombinant)
货号：30174 规格：100 µg 目录价：￥14448
产品详情
产品名称:
Interleukin-6 (human, recombinant)
别名:
B Cell Stimulatory Factor 2|BSF-2|CDF|CTL Differentiation Factor|HGF|HSF|Hybridoma Growth Factor|IFN-β-2|IL-6|Interferon β-2
产品描述:
IL-6 is a cytokine with roles in both the initiation and resolution of inflammatory responses.{46747,46748} IL-6 is produced in response to an inflammatory event, induces recruitment of neutrophils to the site of inflammation, and signals through the membrane-bound IL-6 receptor (IL-6R) to upregulate the synthesis of acute phase proteins, lipolysis in the liver, and induced differentiation of T and B cells. Following initiation of this classical signaling pathway, a soluble form of IL-6R (sIL-6R) is released from neutrophils to promote recruitment of monocytes and macrophages, induction of fever via IL-6 action in the hypothalamus, and production of anti-inflammatory M2 macrophages to initiate tissue repair. Production of IL-6 is dysregulated in various chronic inflammatory diseases, including rheumatoid arthritis, Castleman disease, polymyalgia rheumatica, and giant cell arteritis.{46749} It also induces tumor growth and metastasis via activation of JAK/STAT signaling.{46750} Cayman’s IL-6 (human, recombinant) protein can be used for ELISA, Western blot, and cell-based assay applications. Post-translational modifications such as glycosylation may retard receptor electrophoretic migration such that the protein signal may be detected between 20 and 26 kDa.
实验应用:
ELISA, WB
保存温度:
-80
运输温度:
-80
产品形式:
Active recombinant N-terminal His-tagged IL-6 expressed in Expi293F cells
有效期:
180
纯度:
≥85% estimated by SDS-PAGE
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