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折扣/货期| 货号：14491 | 规格：100 µg | 目录价：￥6720 |
产品详情
产品名称:
BRD7 bromodomain (human, recombinant)
别名:
Bromodomain containing protein 7|Protein CELTIX-1
产品描述:
The acetylation of histone lysine residues plays a crucial role in the epigenetic regulation of gene transcription. Acetylated lysine residues are recognized by a small protein domain known as a bromodomain.{19952} These domains function in linking protein complexes to acetylated nucleosomes, thereby controlling chromatin structure and gene expression. Thus, bromodomains serve as “readers” of histone acetylation marks regulating the transcription of target promoters.{20313} BRD7 is a subunit of the polybromo-associated BRG1-associated factor (PBAF)-specific component of the switch/sucrose non-fermentable chromatin-remodeling complex.{23106} It has a tumor suppressor role by acting as a cofactor for p53 and regulating breast cancer tumorigenicity.{23107,23108} Cells lacking BRD7 have reduced breast cancer type 1-dependent estrogen receptor α expression.{23108} Down-regulation of BRD7 has been demonstrated in nasopharyngeal carcinoma cell lines and in colorectal cancer.{23109,23107} BRD7 is also involved in transcriptional gene silencing through binding to protein arginine methyltransferase 5 and polycomb repressive complex 2. This protein product contains the bromodomain region of BRD7.
保存温度:
-80
运输温度:
-80
产品形式:
50 mM Tris, pH 8.0, with 150 mM sodium chloride and 20% glycerol
有效期:
730
纯度:
≥70% estimated by SDS-PAGE
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