官网链接
折扣/货期| 货号：14490 | 规格：100 µg | 目录价：￥5026 |
产品详情
产品名称:
ATAD2 bromodomain (human recombinant)
别名:
ANCCA|ATPase Family AAA Domain-containing Protein 2
产品描述:
The acetylation of histone lysine residues plays a crucial role in the epigenetic regulation of gene transcription. Acetylated lysine residues are recognized by a small protein domain known as a bromodomain.{19952} These domains function in linking protein complexes to acetylated nucleosomes, thereby controlling chromatin structure and gene expression. Thus, bromodomains serve as "readers" of histone acetylation marks regulating the transcription of target promoters.{20313} ATAD2 is an AAA+ ATPase-containing nuclear transcriptional coactivator for the estrogen and androgen receptors.{22880,22881} ATAD2 is highly expressed in several types of tumors and has been proposed to link the E2F and MYC signaling pathways. Binding to the MYC oncogene stimulates its transcriptional activity, leading to the development of aggressive cancers with poor prognosis.{22878} ATAD2 is important for the assembly of chromatin modifying complexes and its bromodomain associates with acetylated lysine 14 on histone H3 to regulate the genes required for cell cycle progression.{22880,22879}
保存温度:
-80
运输温度:
-80
产品形式:
50 mM Tris, pH 8.0, containing 150 mM sodium chloride and 20% glycerol
有效期:
365
纯度:
≥90%
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