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折扣/货期| 货号：AG-40T-0103-C050 | 规格：50 ug | 目录价：￥4680 |
产品详情
产品名称:
Zmp1 (M. tuberculosis) (rec.) (His)
别名:
Zinc Metalloprotease 1; Endopeptidase; Rv0198c
产品描述:
M13 endopeptidases are single-pass, transmembrane zinc-metallopeptidases responsible in human for the regulation of the biological activity of many hormones and peptides and are involved in many important processes such as blood pressure regulation (Neprilysin or NEP1), cardiovascular development (Endothelin Converting Enzyme-1 or ECE-12), prevention of haemolytic reaction (KELL) and phosphate homeostasis (PHEX). Zmp1 is a soluble enzyme member of the M13 endopeptidases family that plays a key role in Mycobacterium tuberculosis pathogenicity with a still unknown mechanism. Recently, it was shown to suppress inflammasome activation by inhibiting caspase-1 activation, thus preventing processing of pro-IL-1beta into IL-1beta and the consequent phagosome maturation.
宿主来源:
E. coli
靶标/特异性:
Prefered cleavage sequence is PxxF.
产品浓度:
0.5mg/ml (Lot specific)
保存温度:
-80°C
运输温度:
DRY ICE
预期分子量:
~73.9kDa
产品形式:
liquid
存储溶液:
Liquid. In 10mM TRIS-HCl, pH 8.0.
有效期:
Stable for at least 6 months after receipt when stored at -80°C.
产地:
瑞士
纯度:
>98% (SDS-PAGE)
生物活性:
~0.5U/mg protein. Active towards the generic fluorogenic substrate for matrix metalloproteinases MMP2/MMP7 (Lit. 1).
内毒素水平:
N/A
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