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Kynurenine Aminotransferase II (human) (rec.) (His)
品牌：Adipogen
货号：AG-40T-0102-C050 规格：50 ug 目录价：￥4680
产品详情
产品名称:
Kynurenine Aminotransferase II (human) (rec.) (His)
别名:
hKAT II; KAT2; alpha-Aminoadipate Aminotransferase (Mitochondrial); AADAT; EC 2.6.1.7
产品描述:
Kynurenine aminotransferases (KATs) are pyridoxal-5’-phosphate-dependent enzymes that catalyze the conversion of L-kynurenine into kynurenic acid, a neuroactive metabolite whose unbalancing is associated with a number of brain disorders. Biochemical and structural investigations revealed that L-kynurenine (L-KYN) recognition by hKAT II is achieved by exploiting structural features that are peculiar of this isoform, thus offering the possibility to select/design inhibitor molecules specifically targeting hKAT II to be used as modulators of kynurenic acid synthesis in the CNS. hKAT II is one of the aminotransferases involved in the pyridoxal 5'-phosphate (PLP)-dependent irreversible transamination of L-kynurenine (L-KYN) to kynurenic acid (KYNA) in the central nervous system. When assayed in vitro the protein also displays beta-elimination activity.
宿主来源:
E. coli
产品浓度:
0.5mg/ml (Lot specific)
保存温度:
-80°C
运输温度:
DRY ICE
预期分子量:
~49.8kDa
产品形式:
liquid
存储溶液:
Liquid. In 50 mM phosphate buffer pH 8.0, containing 50mM sodium chloride and 40µM pyridoxal 5'-phosphate (PLP).
有效期:
Stable for at least 6 months after receipt when stored at -80°C.
产地:
瑞士
纯度:
>97% (SDS-PAGE)
内毒素水平:
N/A
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