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折扣/货期| 货号：CDX-T0449-M010 | 规格：10 mg | 目录价：￥896 |
| 货号：CDX-T0449-M050 | 规格：50 mg | 目录价：￥3556 |
产品详情
产品名称:
Trilostane
别名:
Desopan; Modrefen; Vetoryl; WIN 24,540
产品描述:
Trilostane is an inhibitor of the 3beta-HSDs (3beta-HSD1 and 3beta-HSD2 with Ki values of 0.10 and 1.60 µM, respectively) which plays a role in adrenal steroid biosesynthesis. 3beta-hydroxysteroid dehydrogenase (3beta-HSD) type 1 and type 2 isoforms are key enzymes for the biosesynthesis of all active steroid hormones. 3beta-HSD1 (type I) is expressed in placenta and peripheral tissues including breast tumors, whereas 3beta-HSD2 (type 2) is expressed in the adrenal gland, ovary and testis. While Trilsotane has been approved for use in the treatment of Cushing’s syndrome in dogs to reduce cortisol, aldosterone and corticosterone levels, it is being investigated as a possible treatment for both breast cancer and prostate cancer to prevent the synthesis of estrogens and androgens from endogenous precursors. Trilostane has also anti-inflammatory and analgesic properties and systemic administration of trilostane directly affected peripheral and brain levels in neuroactive steroids and monoamine turnover, resulting in antidepressant activity.
宿主来源:
Synthetic
保存温度:
+4°C
运输温度:
Ambient
预期分子量:
329.43
产品形式:
solid
有效期:
Stable for at least 2 years after receipt when stored at +4°C.
产地:
瑞士
纯度:
>98% (HPLC)
CAS号:
13647-35-3
分子式:
C20H27NO3
溶解度:
Soluble in DMSO (15mg/ml) or DMF (20mg/ml).
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