Thioredoxin 1 (human, recombinant)-其他重组蛋白-ELISA_抗体_蛋白_核苷酸

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Thioredoxin 1 (human, recombinant)

品牌：Cayman

官网链接

说明书

折扣/货期

货号：31038

规格：100 µg

目录价：￥5376

产品详情

产品名称:

Thioredoxin 1 (human, recombinant)

别名:

Trx1|Txn1

产品描述:

Thioredoxin 1 (Trx1) is a thiol-disulfide oxidoreductase and part of the antioxidant thioredoxin system that is involved in the maintenance of cellular thiol redox homeostasis.{57135,57136,57138} It is ubiquitously expressed, localizes primarily to the cytoplasm with some nuclear localization, and is upregulated in and released from cells under conditions of oxidative stress.{57135,57136,57137} Trx1 contains two active site cysteine residues at positions 32 and 35, with additional cysteines at positions 62, 69, and 73.{57136} During the catalytic cycle, the active site cysteines are oxidized to a disulfide upon reduction of oxidized protein disulfide substrates and are subsequently restored to their reduced state by thioredoxin reductase (TrxR) and NADPH.{57135,57136} It regulates redox-sensitive transcription factors including NF-κB, p53, and the glucocorticoid receptor, as well as inhibits apoptosis through redox-sensitive binding and regulation of apoptosis signal-regulating kinase 1 (ASK1).{57136,57137} Exogenous administration of extracellular recombinant human Trx1 has anti-inflammatory effects in a variety of animal models.{57136} Trx1 levels are increased in a variety of human primary tumors, and increased tumor levels of Trx1 are associated with decreased survival in patients with colorectal cancer.{57137} Cayman's Thioredoxin 1 (human, recombinant) protein can be used for enzyme activity assay and Western blot (WB) applications.

宿主来源:

E. coli

保存温度:

-80

运输温度:

-80

产品形式:

50 mM Tris-HCl, pH 7.8, with 150 mM sodium chloride, 10% glycerol, 1 mM EDTA, and 0.1 mM DTT

有效期:

365

纯度:

≥95% estimated by SDS-PAGE