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TDZD-8

品牌：Adipogen

官网链接

说明书

折扣/货期

货号：AG-CR1-3740-M005	规格：5 mg	目录价：￥600
货号：AG-CR1-3740-M025	规格：25 mg	目录价：￥1080

产品详情

产品名称:

TDZD-8

别名:

NP 01139; 2-Methyl-4-(phenylmethyl)-1,2,4-thiadiazolidine-3,5-dione

产品描述:

TDZD-8 is a non-ATP competitive selective inhibitor of the serine/threonine kinase glycogen synthase kinase 3beta (GSK3beta; IC50 = 2µM), binding to the active site of GSK3beta. It does not significantly affect the activities of Cdk-1/cyclin B, CK-II, cAMP-dependent protein kinase or protein kinase C (IC50s = >100 µM), but inhibits PKC and Flt-3 activities (IC50 = 1.4-5.5µM and 673nM, respectively). TDZD-8 has been used to study the role of GSK3beta during stem cell differentiation as well as in cell and animal models of Alzheimer’s disease and other neurodegenerative disorders. TDZD-8 is a potent anti-proliferative and pro-apoptotic agent of glioma cells in vitro and in vivo. These effects are associated with an early activation of extracellular signal-regulated kinase (ERK), which is followed by an increased expression of the early growth response-1 (EGR-1) and p21. TDZD-8 potentially inhibits the 33.8-kDa Main protease (Mpro)/3C-like protease of SARS-CoV-2, consequently inhibiting viral transcription and replication and possibly inhibiting spread of COVID-19.

保存温度:

-20°C

运输温度:

Ambient

预期分子量:

222.3

产品形式:

solid

有效期:

Stable for at least 2 years after receipt when stored at -20°C.

产地:

瑞士