α-Synuclein Monoclonal Antibody-单抗-ELISA_抗体_蛋白_核苷酸_试剂盒-深圳九游会j9网站首页有限公司

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α-Synuclein Monoclonal Antibody

品牌：Cayman

官网链接

说明书

折扣/货期

货号：29251

规格：100 µl

目录价：￥6736

产品详情

产品名称:

α-Synuclein Monoclonal Antibody

别名:

SNCA|α-Syn

产品描述:

α-Synuclein is a 140-amino acid intracellular protein encoded by the SNCA gene in humans.{46939} It is primarily localized to the synaptic terminal of neurons in both the central and peripheral nervous systems where it has a role in regulation of synaptic vesicle docking and neurotransmitter release.{46938} α-Synuclein is an intrinsically disordered, multi-domain protein composed of a negatively charged C-terminal domain that provides structural flexibility, a central hydrophobic region with a high propensity to aggregate, and a positively charged N-terminal domain containing a repeated consensus sequence KTKEGV.{46939,46937} It exists as monomer in the cytoplasm, however, mutations, posttranslational modifications, and changes in cellular environmental conditions can induce oligomerization and aggregate formation. Aggregated α-synuclein is found in Lewy bodies that occur in Parkinson’s disease and diffuse Lewy body disease, as well as in glial cells in postmortem brains from patients with multiple system atrophy (MSA) and amyotrophic lateral sclerosis (ALS). Cayman's α-Synuclein Monoclonal Antibody can be used for immunocytochemistry (ICC) and Western blot (WB) applications. The antibody recognizes α-synuclein at approximately 15 kDa from human, mouse, and rat samples.

宿主来源:

Mouse

实验应用:

ICC and WB

同种型:

IgG1

免疫原:

Full-length human α-synuclein expressed in E. coli

保存温度:

-20

运输温度:

-20