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SETD3 Monoclonal Antibody (Clone 1B4)
货号：29208 规格：100 µg 目录价：￥4410
产品详情
产品名称:
SETD3 Monoclonal Antibody (Clone 1B4)
别名:
Actin Histidine N-Methyltransferase|C14orf154|Chromosome 14 Open Reading Frame 154|HSETD3|SET Domain-containing 3, Actin Histidine Methyltransferase|SET Domain-containing Protein 3
产品描述:
SET domain protein 3 (SETD3) is an actin histidine methyltransferase encoded by the SETD3 gene in humans and a member of the SET family of methyltransferases.{53440} It contains an N-terminal SET domain, responsible for transferring a methyl group from S-adenosyl methionine to histidine 73 on β-actin, that forms a cleft with a C-terminal domain that is similar to large subunit methyltransferase (LSMT) domains.{35557} SETD3 is ubiquitously expressed and localizes to the cytoplasm. SETD3 overexpression in liver cancer cell lines increases proliferation while shRNA knockdown decreases it.{53440} Overexpression of SETD3 increases tumor size in a HepG2 mouse xenograft model, and a xenograft model using cancer cells with an endogenous knockdown of SETD3 reduces tumor size. SETD3 protein levels are increased in isolated human cancer tissues compared with adjacent tissue. Setd3 knockout in mice leads to skeletal muscle myopathy, abnormal cardiac electrocardiogram, and, in female mice, delayed parturition.{35557} Cayman's SETD3 Monoclonal Antibody (Clone 1B4) can be used for ELISA and Western blot applications. The antibody recognizes SETD3 at 67 kDa from human samples.
宿主来源:
Mouse
实验应用:
ELISA, WB
同种型:
IgG1
免疫原:
Full-length recombinant human SETD3 protein
克隆号:
1B4
保存温度:
-20
运输温度:
-20
产品形式:
100 µg of protein G-purified monoclonal antibody
有效期:
1095
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