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METTL16 Monoclonal Antibody (Clone 4C9)
货号：29207 规格：100 µg 目录价：￥4410
产品详情
产品名称:
METTL16 Monoclonal Antibody (Clone 4C9)
别名:
EC 2.1.1.346|EC 2.1.1.62|Methyltransferase 10 Domain-containing Protein|Methyltransferase-like Protein 16|N6-Adenosine-methyltransferase METTL16|Putative Methyltransferase METT10D|U6 Small Nuclear RNA (adenine-(43)-N(6))-Methyltransferase|U6 snRNA Methyltransferase METT10D
产品描述:
Methyltransferase-like protein 16 (METTL16) is an m6A RNA methyltransferase encoded by the METTL16 gene in humans and localized to the cell nucleus.{50141,56098} It is composed of a methyltransferase domain that associates with RNA and two vertebrate conserved regions (VCRs) on the C-terminal end that promote splicing.{49283} METTL16 acts as an epigenetic writer by methylating the pre-mRNA of the S-adenosylmethionine (SAM) synthetase MAT2A in the presence of SAM. It also methylates the adenine at position 43 of spliceosome component U6 snRNA and interacts with cancer-associated MALAT1 long non-coding RNA (lncRNA).{35512,50141} Knockout of Mettl16 in mouse embryos leads to a reduction in Mat2a mRNA expression, transcriptome dysregulation, and lethality at approximately the implantation stage.{49284} The expression of METTL16 is increased in isolated human colon, but not rectal, adenocarcinoma tumor tissue, and decreased METTL16 expression in rectal adenocarcinoma tumor tissue is associated with lower overall survival.{49285} Cayman’s METTL16 Monoclonal Antibody (Clone 4C9) can be used for ELISA, Immunofluorescence, and Western blot applications. The antibody recognizes METTL16 at 64 kDa from human samples.
宿主来源:
Mouse
实验应用:
ELISA, IF, and WB
同种型:
IgG1
免疫原:
Full-length recombinant human METTL16
克隆号:
4C9
保存温度:
-20
运输温度:
-20
产品形式:
100 µg of protein G-purified monoclonal antibody
有效期:
1095
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