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STING Y240A variant (Y240A mutant; human, recombinant)
品牌：Cayman
货号：40240 规格：100 µg 目录价：￥8260
产品详情
产品名称:
STING Y240A variant (Y240A mutant; human, recombinant)
别名:
Endoplasmic Reticulum Interferon Stimulator|ERIS|Mediator of IRF3 Activation|MITA|Mitochondrial Mediator of IRF3 Activation|MPYS|N-Terminal Methionine-Proline-Tyrosine-Serine Plasma Membrane Tetraspanner|Stimulator of Interferon Genes|Stimulator of Interferon Response cGAMP Interactor 1|STING1|TMEM173|Transmembrane Protein 173
产品描述:
Stimulator of interferon genes (STING) is a component of the innate immune response that recognizes and binds to cyclic dinucleotides (CDNs), which either originate from bacteria or are signals of intracellular stress, leading to activation of NF-κB and transcription of immunomodulatory genes, including type I interferon (IFN).{24607,22400,22401,24611,69771} The R232 variant is the most common variant in the human population, found at a frequency of 57.9% in the 1000 Genome Project.{38697} STING is composed of four transmembrane domains at the N-terminus, a helix α1 domain involved in protein dimerization and ligand sensing, and a cytoplasmic C-terminal domain containing the cyclic dinucleotide-binding domain, as well as the TBK1/IRF1-binding site, TBK1 phosphorylation site, and IRF3 docking site.{69772} Various mutations in STING either reduce or increase its activity or binding affinity.{38697,41598,34537,24612} The tyrosine-to-alanine substitution at position 240 (Y240A) reduces 2'3'-cGAMP binding to STING and prevents activation of the IFN pathway.{24609}
保存温度:
-80
运输温度:
-80
产品形式:
50 mM HEPES, pH 8.0, 100 mM sodium chloride, 10% glycerol
有效期:
365
纯度:
≥75% estimated by SDS-PAGE
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