Somatotropin Long Isoform (human, recombinant)

Growth Hormone 1|Pituitary Growth Hormone

Somatotropin is a circulating peptide hormone encoded by GH1 in humans that has roles in growth, cellular proliferation and differentiation, muscle and bone anabolism, and lipolysis.{52624} Alternative splicing of the GH1 pre-mRNA produces one full-length 22 kDa isoform and a short-length 20 kDa isoform, which has reduced affinity for the somatotropin receptor.{52625} Somatotropin contains a central hydrophobic core and a bundle of four α-helices that forms two somatotropin receptor binding sites.{52626} It is synthesized and stored by somatotrophs in the anterior pituitary gland and is secreted episodically as a monomer or dimer in a circadian rhythm that peaks during night sleep.{52626,52625} Somatotropin production is induced by stimulation with growth hormone-releasing hormone, ghrelin, or sex steroids and inhibited by somatostatin, IGF-1, or glucocorticoid stimulation.{52627} Binding of somatotropin to the somatotropin receptor, which is ubiquitously expressed, activates a variety of intracellular signal transduction pathways, including JAK-STAT, that lead to IGF-1, MAPK, PPARγ (Item No. 61700), or SIRPα signaling.{52628,52624,52626} Decreased serum levels of somatotropin have been found in patients with dwarfism.{52629} Increased somatotropin serum levels have been found in patients with acromegaly, a condition characterized by abnormal bone growth, and are positively correlated with early mortality.{52629,52630} Cayman's Somatotropin Long Isoform (human, recombinant) protein can be used for cell-based assay applications. This protein consists of 212 amino acids and has a calculated molecular weight of 24.7 kDa.

-80

-80

Lyophilized from sterile PBS, pH 7.4

365

≥85% as determined by SDS-PAGE