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折扣/货期| 货号：10011670 | 规格：50 µg | 目录价：￥4942 |
产品详情
产品名称:
Soluble Epoxide Hydrolase (mouse, recombinant)
别名:
Cytosolic Epoxide Hydrolase (CEH)|EPHX2|Epoxide Hydrolase 2|sEH
产品描述:
Soluble epoxide hydrolase (sEH) is a member of the α/β-hydrolase fold enzyme family that catalyzes the hydrolysis of bioactive fatty acid epoxides to inactive vicinal diols.{52737} It is a homodimer in which each subunit is composed of two domains, a C-terminal epoxide hydrolase domain and an N-terminal phosphatase domain.{52738,15765} sEH is localized to the cytoplasm or to peroxisomes in a tissue-specific manner and is found in various tissues, including skin, lung, uterus, kidney, brain, and myocardium.{52740,52739} sEH is also expressed in the vasculature and inhibition of sEH attenuates pathogenic vascular remodeling and hypertension via preservation of cardioprotective epoxyeicosatrienoic acids (EETs) in rat models of atherosclerosis and hypertension, respectively.{52741} Inhibition of sEH also has a protective role in various diseases, including inflammatory bowel disease, osteoarthritis, seizure, stroke, and Alzheimer’s disease, as well as in various chronic pain states.{52737,50771} Cayman’s Soluble Epoxide Hydrolase (mouse, recombinant) protein can be used for enzyme activity assays.
宿主来源:
Insect cells
保存温度:
-80
运输温度:
-80
产品形式:
TBS buffer at pH 7.4 with 20% glycerol
有效期:
365
纯度:
≥95% estimated by SDS-PAGE
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