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折扣/货期| 货号：700350 | 规格：96 wells | 目录价：￥9646 |
产品详情
产品名称:
SET8 Methyltransferase Inhibitor Screening Assay Kit
别名:
PR-Set7|SET domain-containing (lysine methyltransferase) 8|SETD8
产品描述:
SET Domain-containing Protein 8 (SET8) is a methyltransferase that selectively mono-methylates histone H4 at lysine residue 20 (H4K20), an event proven to have an important role in chromatin structure and transcriptional activation. Cayman’s SET8 Methyltransferase Inhibitor Screening Assay provides a convenient method for screening human SET8 inhibitors. The transfer of the methyl group from SAM by SET8 (provided in the kit) to the acceptor peptide (H4K20) generates S-adenosylhomocysteine, which is rapidly converted to urate and hydrogen peroxide (H2O2) using an enzyme mixture provided in the kit. The H2O2 formed is quantified using 10-acetyl-3,7-dihydroxyphenoxazine (ADHP) to produce the highly fluorescent compound resorufin (excitation 530-540 nm; emission 585-595 nm).
保存温度:
-80
运输温度:
-80
有效期:
365
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