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    SARS-CoV-2 Spike Glycoprotein S2 Subunit (recombinant)
    品牌：Cayman
    货号：31815 规格：100 µg 目录价：￥8874
    产品详情
    产品名称:
    SARS-CoV-2 Spike Glycoprotein S2 Subunit (recombinant)
    别名:
    2019-nCoV Surface Glycoprotein S2 Subunit|COVID-19 Spike Glycoprotein S2 Subunit|SARS-CoV-2 Spike Glycoprotein S2 Subunit|Severe Acute Respiratory Syndrome Coronavirus 2 Spike Glycoprotein S2 Subunit
    产品描述:
    Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an enveloped positive-stranded RNA virus, a member of the Betacoronavirus genus, and the causative agent of COVID-19.{53462,53459,53461,55257,55258} The SARS-CoV-2 spike glycoprotein, also known as the surface glycoprotein, is a viral structural protein encoded by the S gene in SARS-CoV-2 RNA.{53462} It is composed of an S1 and S2 subunit divided by a furin S-cleavage site not found in other SARS-CoVs.{46767,49561} The C-terminal S2 subunit, which facilitates fusion between viral and host cell membranes, contains a fusion peptide (FP) and two heptad repeats (HRs), as well as transmembrane and cytoplasmic domains.{49561,60056} Upon insertion of the FP in the target cell membrane, the HRs form a six-helical bundle (6-HB) that enables SARS-CoV-2 to fuse with the target cell. The SARS-CoV-2 spike glycoprotein S2 subunit increases amyloid-β (1-40) (Aβ40) and Aβ42 levels in primary mouse neuron culture supernatants and the number of hippocampal and cortical Aβ plaques in APPswe/PSEN1dE9 transgenic mice.{67208} Cayman's SARS-CoV-2 Spike Glycoprotein S2 Subunit (recombinant) protein is a disulfide-linked homodimer. The reduced monomer, composed of the SARS-CoV-2 spike glycoprotein S2 subunit (amino acids 686-1,213) fused to mouse IgG1 Fc at its C-terminus, consists of 762 amino acids and has a calculated molecular weight of 84.3 kDa.
    宿主来源:
    Insect cells
    保存温度:
    -80
    运输温度:
    -80
    产品形式:
    Lyophilized from sterile 20 mM Tris, pH 7.0, 300 mM sodium chloride, and 100 mM glycine
    有效期:
    365
    纯度:
    ≥95% estimated by SDS-PAGE
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