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折扣/货期| 货号：200-39-100ug | 规格：100ug | 目录价：￥11600 |
| 货号：200-39-1mg | 规格：1mg | 目录价：￥51397 |
| 货号：200-39-250ug | 规格：250ug | 目录价：￥22431 |
| 货号：200-39-25ug | 规格：25ug | 目录价：￥2910 |
| 货号：200-39-500ug | 规格：500ug | 目录价：￥33338 |
| 货号：200-39-5ug | 规格：5ug | 目录价：￥1169 |
产品详情
产品名称:
Recombinant Human IL-37 (IL-1F7)
别名:
Interleukin-37, IL-1F7, IL-1ζ (zeta), IL-1H4
产品描述:
The IL-1 family is comprised of 11 structurally related ligands, including recently re-named IL-37 (IL-1F7), which acts as a modulator of the immune response. Reduction of IL-37 synthesis in PBMCs leads to increased production of proinflammatory cytokines including IL-1 alpha, IL-1beta, IL-6 and TNF- alpha. The role of IL-37 as an inhibitor of the innate inflammatory response is also corroborated by the observation that it is highly expressed in synovial tissue from patients with rheumatoid arthritis. Full length IL-37 resides primarily in the cytoplasm, but after activation through cleavage by CASP1, it can translocate to the nucleus where it exerts its activity by direct interaction with SMAD3. Recombinant Human IL-37 is a 19.4 kDa protein consisting of 174 amino acids, corresponding to the mature activated form of IL-37.
宿主来源:
E.coli
推荐稀释度:
请严格按照批次特异性说明书中Reconstitution部分指定的溶液溶解蛋白到推荐浓度
预期分子量:
19.4 kDa
产品形式:
Bulk
产地:
美国
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