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折扣/货期| 货号：200-38-100ug | 规格：100ug | 目录价：￥22138 |
| 货号：200-38-10ug | 规格：10ug | 目录价：￥2836 |
| 货号：200-38-1mg | 规格：1mg | 目录价：￥88652 |
| 货号：200-38-250ug | 规格：250ug | 目录价：￥38710 |
| 货号：200-38-2ug | 规格：2ug | 目录价：￥1163 |
| 货号：200-38-500ug | 规格：500ug | 目录价：￥57513 |
| 货号：200-38-50ug | 规格：50ug | 目录价：￥13268 |
产品详情
产品名称:
Recombinant Human IL-27
别名:
Interleukin-27, Interleukin-27 subunit alpha, IL-27-A, Interleukin-27 subunitbeta, IL-27B, Epstein-Barr virus-induced gene 3 protein, EBV-induced gene 3 protein, EBI3, p28, Interleukin-30, IL30
产品描述:
As a member of the IL-12 family of heterodimeric cytokines that also includes IL-12, IL-23, and IL-35, IL-27 is formed by the association of an IL-27-p28 subunit (also known as IL-30) with the Epstein-Barr Virus (EBV)-induced Gene 3 (EBI3) subunit (also known as IL-27B). Expressed by antigen-presenting cells (APCs) in the early phases of antigen-mediated activation, IL-27 acts as a critical initiator of adaptive immune responses by promoting the rapid clonal expansion of naive CD4+ T cells, IFN-gamma production, and Th1 polarization. IL-27 elicits its effects through receptor complexes IL-27R (also known as TCCR/WSX-1) and gp130, a receptor shared by IL-6. Mainly expressed in monocytes, endothelial cells, and dendritic cells, IL-27 plays an important role alongside IL-6 in the regulation of inflammation and autoimmunity; directly antagonizing IL-6's stimulation of CD4+ T cell proliferation and Th17 differentiation. Recombinant Human IL-27 produced from HEK293 cells is a non-disulfide-linked, heterodimeric protein composed of a 209 amino acid length EBI3 subunit and a 215 amino acid length IL-27-p28 subunit, for a total sequence length of 424 amino acid residues. The calculated molecular weight of the associated IL-27 subunits is 47.8 kDa.
宿主来源:
HEK293 cells
推荐稀释度:
请严格按照批次特异性说明书中Reconstitution部分指定的溶液溶解蛋白到推荐浓度
预期分子量:
47.8 kDa
产品形式:
Bulk
产地:
美国
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