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Palmitoyl Ethanolamide
品牌：Cayman
货号：90350-10 mg 规格：10 mg 目录价：￥700
货号：90350-100 mg 规格：100 mg 目录价：￥4270
货号：90350-5 mg 规格：5 mg 目录价：￥448
货号：90350-50 mg 规格：50 mg 目录价：￥2366
产品详情
产品名称:
Palmitoyl Ethanolamide
别名:
Palmidrol|Palmityl Ethanolamide|PEA
产品描述:
Palmitoyl ethanolamide (PEA) is an endogenous fatty N-acyl ethanolamine and a derivative of the endocannabinoid arachidonoyl ethanolamide (AEA; Item No. 90050).{2415,2714} It selectively activates peroxisome proliferator-activated receptor α (PPARα; EC50 = 3.1 µM) over PPARβ/δ and PPARγ in HeLa cells expressing the human receptors.{67463} PEA binds to RBL-2H3 basophil membranes (IC50 = 1 nM), which endogenously express cannabinoid 2 (CB2), but not CB1, receptors, and inhibits antigen-induced serotonin release from RBL-2H3 cells (EC50 = 0.27 µM).{2714} It prevents decreases in paw withdrawal latency in a radiant heat hypersensitivity test, an effect that can be reversed by the CB1 receptor antagonist SR141716 (rimonabant; Item No. 9000484), PPARγ antagonist GW 9662 (Item No. 70785), and transient receptor potential vanilloid 1 (TRPV1) antagonist capsazepine (Item No. 10007518), in a mouse model of neuropathic pain induced by chronic constriction injury of the sciatic nerve.{67464} PEA (10 mg/kg) decreases carrageenan-induced paw edema in wild-type, but not Ppara-/-, mice.{67463} It inhibits tonic convulsions induced by pentylenetetrazole (PTZ; Item No. 18682) in rats when administered at a dose of 40 mg/kg.{13324} Formulations containing palmitoyl ethanolamide have been used as dietary supplements.
保存温度:
-20
运输温度:
-20
预期分子量:
299.5
产品形式:
A crystalline solid
有效期:
1460
纯度:
≥98%
CAS号:
544-31-0
分子式:
C18H37NO2
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