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折扣/货期| 货号：38054 | 规格：50 µg | 目录价：￥3204 |
产品详情
产品名称:
Osteomodulin (human, recombinant)
别名:
Keratan Sulfate Proteoglycan Osteomodulin|KSPG Osteomodulin|OMD|OSAD|Osteoadherin
产品描述:
Osteomodulin (OMD), is a class II keratan sulfate small leucine-rich proteoglycan (SLRP) with roles in bone mineralization, cell adhesion, tooth formation, and the regulation of collagen fibrils.{64867,64868} It is primarily expressed in mineralized tissues, including bones and teeth, but is also expressed in articular chondrocytes and fibrochondrocytes.{64867} OMD binds to bone morphogenetic protein 2 (BMP2), promoting SMAD signaling and osteogenesis. It also binds to type I collagen and induces morphology and size changes in collagen fibrils, indicating a role in the regulation of extracellular matrix components during bone formation.{64868} Increased plasma levels of OMD are associated with cardiac calcification in patients with chronic kidney disease (CKD).{64870} Serum levels of OMD are increased and positively correlated with plaque calcification in patients with carotid atherosclerosis. Serum levels of OMD are also decreased in patients with osteoarthritis.{64869} Cayman’s Osteomodulin (human, recombinant) protein consists of 412 amino acids, has a calculated molecular weight of 48.6 kDa, and a predicted N-terminus of Gln21 after signal peptide cleavage.
保存温度:
-80
运输温度:
-80
产品形式:
Lyophilized from sterile PBS, pH 7.4
有效期:
365
纯度:
≥95% as determined by SDS-PAGE
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