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Nucleosome, Recombinant Human, Acidic Patch Mutant H2BE105A,E113A Biotinylated
品牌：EpiCypher
货号：16-0031 规格：50 µg 目录价：￥5700
产品详情
产品名称:
Nucleosome, Recombinant Human, Acidic Patch Mutant H2BE105A,E113A Biotinylated
产品描述:
Recombinant mononucleosomes consist of 147 base pairs of DNA wrapped around an octamer core of histone proteins (two each of H2A, H2B, H3.1, and H4) to form a nucleosome, the basic repeating unit of chromatin. The 147 bp 601 sequence containing a 5’ biotin-TEG group has high affinity for histone octamers and is useful for nucleosome assembly [1]. Histone H2B contains a glutamate-to-alanine (E-to-A) substitution at positions 105 and 113 (H2BE105A, E113A). H2BE105 and H2BE113 are among key residues forming a negatively charged region on the nucleosome surface named the “acidic patch”. The acidic patch is a conserved interaction hub for neighboring nucleosomes and nucleosome binding proteins, often via salt bridges with arginine anchors, and is functionally critical in chromatin condensation and chromatin remodeling [2-4]. H2B 105 and E113 both reside in H2B alphaC extension and are associated with nucleosome binding factors such as histone H4 N-terminal tail, LANA, RCC1, HMGN2, and SMARCB1 [2,5].
宿主来源:
Human
表达系统:
E. coli & synthetic DNA
保存温度:
Stable for six months at -80°C from date of receipt. For best results, aliquot and avoid freeze/thaws.
运输温度:
Dry ice.
产品形式:
0.884 mg/mL mononucleosome in 56.5 μL 10 mM Tris-HCl pH 7.5, 25 mM NaCl, 1 mM EDTA, 2 mM DTT, 20% glycerol. (27.3 μg protein, 50 μg DNA + protein)
产地:
美国
生产商:
EpiCypher
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