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Nucleosome, Recombinant Human, Acidic Patch Mutant H2BE105A,E113A
品牌：EpiCypher
货号：16-1031 规格：50 µg 目录价：￥5700
产品详情
产品名称:
Nucleosome, Recombinant Human, Acidic Patch Mutant H2BE105A,E113A
产品描述:
Mononucleosomes assembled from recombinant human histones expressed in E. coli (two each of histones H2A, H2B*, H3 and H4; accession numbers: H2A-P04908; H2B-O60814*; H3.1-P68431; H4-P62805) wrapped by 147 base pairs of 601 positioning sequence DNA [1]. *Histone H2B contains a glutamate-to-alanine (E-to-A) substitution at positions 105 and 113 (H2BE105A,E113A). H2BE105 and H2BE113 are among key residues forming a negatively charged region on the nucleosome surface named the “acidic patch”. The acidic patch is a conserved interaction hub for neighboring nucleosomes and nucleosome binding proteins, often via salt bridges with arginine anchors, and is functionally critical in chromatin condensation and chromatin remodeling [2-4]. H2B E105 and E113 both reside in the H2B alphaC extension and are associated with nucleosome binding factors such as histone H4 N-terminal tail, LANA, RCC1, HMGN2 and SMARCB1 [2,5].
保存温度:
Stable for six (6) months at -80°C from date of receipt. For best results, aliquot and avoid multiple freeze/thaws.
运输温度:
Dry ice.
产品形式:
H2BE105A,E113A mononucleosomes (27.3 μg protein weight, 50 μg DNA + protein) in 19.7 μL 10 mM Tris HCl pH 7.5, 25 mM NaCl, 1 mM EDTA, 2 mM DTT, 20% glycerol. Molarity = 12.75 μM. MW = 199,028.7 Da.
产地:
美国
生产商:
EpiCypher
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