Nucleophosmin (human, recombinant)-其他重组蛋白-ELISA_抗体_蛋白_核苷酸

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Nucleophosmin (human, recombinant)

品牌：Cayman

官网链接

说明书

折扣/货期

货号：37621

规格：100 µg

目录价：￥6790

产品详情

产品名称:

Nucleophosmin (human, recombinant)

别名:

NPM|NPM1|Nucleolar Phosphoprotein B23|Nucleolar Protein NO38|Numatrin

产品描述:

Nucleophosmin is a nucleolar phosphoprotein that is involved in diverse biological processes, including ribosome maturation, DNA repair, and mitotic spindle assembly.{69419} It is highly post-translationally modified and composed of an oligomerization domain, which contains two nuclear export signals, three acidic domains, an intrinsically disordered region, which contains two nuclear localization signals, and a C-terminal RNA-binding domain.{69419,69420} Nucleophosmin is ubiquitously expressed and shuttles between the nucleolus and cytoplasm, however, alternative splicing of NPM1 produces a variant that lacks the RNA-binding domain and nucleolar localization signal and is instead localized throughout the nucleus.{69421,69419,69420} Nucleophosmin has histone- and protein chaperone activity and plays a role in ribosome assembly and export, centrosome duplication, cell cycle control, the stress response, and embryogenesis.{69419} Knockdown of NPM1 inhibits protein synthesis and the nuclear export of the 40S, 60S, and 80S ribosomal subunits in vitro and knockout of NPM1 is embryonic lethal in mice.{68459,68460} Nucleophosmin fusion proteins have been found in patients with acute promyelocytic leukemia or non-Hodgkin's lymphoma.{68461,60149}

宿主来源:

E. coli

保存温度:

-80

运输温度:

-80

产品形式:

50 mM HEPES, pH 7.8, with 150 mM sodium chloride and 10% glycerol

有效期:

180

纯度:

≥60% estimated by SDS-PAGE