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Nelfinavir . mesylate
品牌：Adipogen
货号：AG-CR1-3726-M010 规格：10 mg 目录价：￥600
货号：AG-CR1-3726-M050 规格：50 mg 目录价：￥2400
产品详情
产品名称:
Nelfinavir . mesylate
别名:
AG-1343; Nelfin; Viracept
产品描述:
Nelfinavir is an orally bioavailable competitive inhibitor of the human immunodeficiency virus. It potently inhibits HIV-1 (Ki=2nM) and HIV-2 protease in vitro. HIV-1 protease is important for the replication of the virus within the cell and the release of mature viral particles from the infected cell. Formulations containing nelfinavir have been used in combination with HIV reverse transcriptase inhibitors for the treatment of AIDS. Nelfinavir shows other antimicrobial and antiviral activity. It inhibits maturation and export of the Herpes Simplex 1 virus and the Kaposi's Sarcoma virus, replication of SARS-CoV and also replication of SARS-CoV-2, cause for the epidemic COVID-19. Has potent anti-cancer activity against a broad selection fo cancer cell types. Shown to induce apoptosis, autophagy, cell cycle arrest and endoplasmic reticulum stress, which consequently leads to cancer cell death. Shown to inhibit the Akt/PKB signaling pathway. It acts as an antifibrotic agent and is used to treat pulmonary fibrosis in patients with systemic sclerosis (SSc) and reduces inflammation by activating protein phosphatase 2 (PP-2) and blocking mitogen-activated protein kinases (MAPK) signaling in macrophages. It has also shown pan-proteasome inhibition in AMO-1 and U266 myeloma cells.
保存温度:
-20°C
运输温度:
Ambient
预期分子量:
567.8 . 96.1
产品形式:
solid
有效期:
Stable for at least 2 years after receipt when stored at -20°C.
产地:
瑞士
纯度:
>98% (HPLC)
CAS号:
159989-65-8
分子式:
C32H45N3O4S . CH4SO3
溶解度:
Soluble in DMSO (15mg/ml), DMF (20mg/ml) or ethanol (20mg/ml).
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