MeCP2 (human recombinant; methyl binding domain aa 77-166)-其他重组蛋白-ELISA_抗体_蛋白_核苷酸

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MeCP2 (human recombinant; methyl binding domain aa 77-166)

品牌：Cayman

官网链接

说明书

折扣/货期

货号：11287

规格：100 µg

目录价：￥4858

产品详情

产品名称:

MeCP2 (human recombinant; methyl binding domain aa 77-166)

别名:

Methyl-CpG Binding Protein 2

产品描述:

DNA methylation occurs mainly at the 5’-position of cytosine rings (5-methylcytosine (5mC)). The 5mC bases are found largely in genomic regions with a high frequency of cytosines and guanines, called CpG islands. Methyl-CpG binding protein 2 (MeCP2) specifically binds to methylated promoters on CpG islands and mediates gene silencing by recruiting corepressor complexes.{20308} The Methyl-CpG Binding Domain (MBD) protein family consists of five members: MeCP2, MBD1, MBD2, MBD3 and MBD4.{20692,20693,17996} The sequence similarity between the MBD proteins is limited to the MBD domains.{20691} In vitro work suggests high affinity binding of MeCP2 is facilitated by DNA fragments containing A/T bases ([A/T]≥4) adjacent to the methyl-CpG.{20309} Mutations in the MeCP2 gene have been linked to the X-linked neurological disorder, Rett Syndrome.{20806}

保存温度:

-80

运输温度:

-80

产品形式:

50 mM Tris, pH 7.5, with 500 mM sodium chloride, 5% glycerol, and 5 mM β-mercaptoethanol

有效期:

365

纯度:

≥95%

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