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折扣/货期| 货号：11451 | 规格：100 µg | 目录价：￥6720 |
产品详情
产品名称:
Irisin (human, recombinant)
别名:
Fibronectin Type III Domain 5|FNDC5|FRCP2|PeP
产品描述:
Physical exertion and exercise are the primary defenses against obesity, insulin resistance, and diabetes. The transcriptional co-activator peroxisome proliferator-activated receptor C coactivator 1α (PGC-1α), regulates mitochondrial biogenesis and function.{21133} Expression of the membrane protein Fibronectin type III domain-containing protein 5 (FNDC5) is stimulated in muscle by PGC-1α in response to exercise. FNDC5 is proteolytically cleaved and secreted as the hormone peptide irisin (named after the Greek goddess messenger Iris). Irisin has been shown to convert white adipose fat to brown adipose fat upon physical exertion. Brown adipose fat allows for mitochondrial uncoupling leading to thermogenetic programs and heat expenditure.{20433} The physiological responses induced by the effects of irisin have the potential to increase weight loss and reduce insulin resistance and obesity.
保存温度:
-80
运输温度:
-80
产品形式:
50 mM Tris pH 8.0, 150 mM sodium chloride, and 20% glycerol
有效期:
365
纯度:
≥85% estimated by SDS-PAGE
CAS号:
9037-90-5
上一个:JMJD2D Strep-tagged (human recombinant)
下一个:Thioredoxin 1 (C61S/C72S mutant; human, recombinant)
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