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折扣/货期| 货号：11300 | 规格：100 µg | 目录价：￥6720 |
产品详情
产品名称:
JMJD2D Strep-tagged (human recombinant)
别名:
Jumonji Domain Containing 2D|KDM4D|Lysine-specific Demethylase 4D
产品描述:
Methylation of lysine residues in core histones plays a critical role in regulating gene expression.{18003} Jumonji domain containing 2D (JMJD2D) catalyzes the demethylation of di- and tri-methylated forms of histone H3 at lysine residue 9 (me 2/3), leading to transcriptional repression and activation, respectively.{18004} Like other JmjC protein hydroxylase family members, JMJD2D is an α-ketoglutarate-dependent Fe (II) oxygenase.{17970} Purification of Fe-dependent JmjC family members by IMAC can result in displacement of the catalytic iron and decreased activity, therefore this Strep-tagged protein is purified by affinity chromatography using Strep-Tactin coated resin.{20824} Because of their implication in cancer cell growth, jumonji C domain-containing histone demethylase inhibitors may have the capacity to be anticancer agents.{18003}
保存温度:
-80
运输温度:
-80
产品形式:
20 mM HEPES, pH 7.4, and 150 mM sodium chloride
有效期:
180
纯度:
≥70% estimated by SDS-PAGE
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