官网链接
折扣/货期| 货号：GTX04505-pro | 规格：50μg | 目录价：￥9300 |
产品详情
产品名称:
Human H-Ras (G12V mutant) protein, His tag
别名:
HRas proto-oncogene, GTPase , C-BAS/HAS , C-H-RAS , C-HA-RAS1 , CTLO , H-RASIDX , HAMSV , HRAS1 , KRAS , KRAS2 , Ki-Ras , RASH1 , RASK2 , c-K-ras , c-Ki-ras , p21ras
克隆号:
偶联:
Unconjugated
产品浓度:
表达系统:
E. coli
保存温度:
Store at -20ºC or below. After reconstitution, keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid freeze-thaw cycles.
运输温度:
4°C
预期分子量:
21
产品形式:
Lyophilized powder
存储溶液:
Reconstitute with ddH₂O to 0.2 mg/mL. Do not vortex. Lyophilized from 10 mM Hepes (pH7.4), 500 mM NaCl, 5% trehalose, no preservatives.
产地:
美国
功能与背景:
This gene belongs to the Ras oncogene family, whose members are related to the transforming genes of mammalian sarcoma retroviruses. The products encoded by these genes function in signal transduction pathways. These proteins can bind GTP and GDP, and they have intrinsic GTPase activity. This protein undergoes a continuous cycle of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. Mutations in this gene cause Costello syndrome, a disease characterized by increased growth at the prenatal stage, growth deficiency at the postnatal stage, predisposition to tumor formation, cognitive disability, skin and musculoskeletal abnormalities, distinctive facial appearance and cardiovascular abnormalities. Defects in this gene are implicated in a variety of cancers, including bladder cancer, follicular thyroid cancer, and oral squamous cell carcinoma. Multiple transcript variants, which encode different isoforms, have been identified for this gene. [provided by RefSeq, Jul 2008]
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