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折扣/货期| 货号：22734 | 规格：50 µg | 目录价：￥3388 |
产品详情
产品名称:
Hsp90α (human recombinant)
别名:
Heat Shock Protein 90α
产品描述:
Heat shock protein 90 α (Hsp90α) is the inducible cytosolic isoform of Hsp90 that is encoded by HSP90AA in humans.{17930} Hsp90 is a multidomain protein that functions as a molecular chaperone to assist in folding and activation of nascent peptides, refolding unfolded or misfolded proteins, and preventing protein aggregation.{15502} C-terminal dimerization of Hsp90, coupled with ATPase molecular clamp activity induces a conformational change in the N-terminal nucleotide binding domain that facilitates substrate binding and initiates the chaperone cycle.{17932} Hsp90 interacts with many co-chaperones during its chaperone cycle including p23 and Sba1, which help recruit substrates to the Hsp90 complex, Hsp70 (Item Nos. 22739 | 23002), which loads nascent polypeptides onto the Hsp90 dimer, and the ATPase activator Aha1 that promotes ATP hydrolysis and substrate release.{17931,41851} Hsp90 is overexpressed in cancer cells and stabilizes client proteins that promote oncogenesis, including transcription factors, signaling proteins, and kinases.{17930,41851} Hsp90 also decreases α-synuclein fibril formation and toxicity as well as Q35 aggregation in in vitro models of Parkinson's and Huntington's disease, respectively, implying a role in neurodegenerative disease.{41852}
保存温度:
-80
运输温度:
-80
产品形式:
50 mM HEPES, pH 7.2, with 100 mM sodium chloride, 5 mM magnesium dichloride, 1mM dithiothreitol, and 20% glycerol
有效期:
180
纯度:
≥90% as estimated by SDS-PAGE
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