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折扣/货期| 货号：11080 | 规格：500 µg | 目录价：￥6720 |
产品详情
产品名称:
Histone H2A Type 1 (human, recombinant)
别名:
H2A Clustered Histone 11|H2A Histone Family, Member P|H2A.1|H2AC11|H2AFP|HIST1H2AG|Histone H2A/ptl
产品描述:
Histone H2A type 1 (H2A.1) is a variant of the histone H2A protein that is encoded by H2AC11, previously known as HIST1H2AG, in humans.{53236} Histone H2A is a core histone that forms a dimer with histone H2B.{46631} Two histone H2A/H2B dimers form an octameric nucleosome with a histone H3/H4 tetramer, around which DNA wraps, allowing it to be condensed. Histone H2A can be post-translationally modified via methylation of the arginine at position 3 by protein arginine methyltransferase 1 (PRMT1), PRMT5, or PRMT6, which is associated with both transcriptional activation and repression.{46198} When methylated by PRMT7, it is associated with DNA damage repair. The arginine residue at position 3 of histone H2A is also subject to citrullination by protein arginine deiminase 4 (PAD4). H2A.1 levels are higher in peripheral blood mononuclear cells (PBMCs) isolated from patients with active systemic lupus erythematosus (SLE) compared to those with stable SLE, rheumatoid arthritis (RA), or non-SLE non-RA controls.{46632} Cayman’s Histone H2A Type 1 (human, recombinant) protein can be used for Western blot and ELISA applications.
保存温度:
-80
运输温度:
-80
产品形式:
A solution in water
有效期:
365
纯度:
≥90% estimated by SDS-PAGE
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