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折扣/货期| 货号：31827-1 mg | 规格：1 mg | 目录价：￥38358 |
| 货号：31827-100 µg | 规格：100 µg | 目录价：￥5904 |
产品详情
产品名称:
FcγRIIIb/CD16b HNA-1b allotype (human, recombinant)
别名:
FCG3|FCGR3B|FCGR3B* 02|FCR-10|FCRIIIb
产品描述:
Low affinity immunoglobulin γ Fc region receptor IIIb (FcγRIIIb) has roles in neutrophil adhesion, phagocytosis, and the respiratory burst.{59450} It is encoded by the FCGR3B gene in humans and is comprised of two immunoglobulin-like (Ig-like) extracellular domains that bind to IgG Fc and pentraxins, such as C-reactive protein. FcγRIIIb is synthesized as a precursor with a transmembrane domain and four-residue cytoplasmic domain that are cleaved in the endoplasmic reticulum, following which a glycosylphosphatidylinositol (GPI) anchor is added, which allows for membrane association of the mature protein.{59451,59450} It can be expressed as three different allotypes known as human neutrophil antigens HNA-1a, HNA-1b, and HNA-1c, which are characterized by differential antibody binding affinities.{59450} FcγRIIIb is constitutively expressed in neutrophils and a subset of basophils and is shed from the cell surface as a soluble form via proteolytic cleavage during apoptosis or following neutrophil activation.{59450,59452} Copy number variation of FCGR3B is associated with an increased risk of systemic lupus erythematosus (SLE) and primary Sjögren's syndrome.{59453} Cayman's FcγRIIIb/CD16b HNA-1b allotype (human, recombinant) protein consists of 176 amino acids and has a calculated molecular weight of 20 kDa.
保存温度:
-80
运输温度:
-80
产品形式:
Lyophilized from sterile 20 mM Tris (pH 7.4) with 50 mM sodium chloride
有效期:
365
纯度:
≥95% estimated by SDS-PAGE
上一个:PVR/CD155 Extracellular Domain (human, recombinant)
下一个:TNFRSF7/CD27 Extracellular Domain (human, recombinant)
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