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折扣/货期| 货号：10329 | 规格：100 µg | 目录价：￥6650 |
产品详情
产品名称:
Cystathionine γ-Lyase (human, recombinant)
别名:
CGL|CTH|Cystathionase
产品描述:
Transsulfuration and reverse transsulfuration comprise part of the metabolic interconversion of the sulfur-containing amino acids cysteine and methionine.{17812} Reverse transsulfuration is catalyzed by the enzymes cystathionine β-synthase (CBS) and cystathionine γ-lyase (CGL) in fungi and mammals.{17812} Specifically, CGL catalyzes the conversion of cystathionine to cysteine in a pyridoxal-5'-phosphate-dependant reaction.{17811} At elevated levels, homocysteine is an independent risk factor for cardiovascular diseases and other complex disorders.{17811} The mammalian transsulfuration pathway is one of two major metabolic routes for homocysteine removal. Besides homocysteine removal, transsulfuration contributes significantly to the intracellular cysteine pool.{17811} Cysteine is used for biosesynthesis of glutathione, and is also the primary substrate for H2S biosesynthesis. CGL is one of two major enzymes that catalyzes the formation of H2S from cysteine. {17811} H2S generation is a biological gasotransmitter, a neuromodulator, a vasodilator, and plays an important role in inflammation.{17811}
保存温度:
-80
运输温度:
-80
产品形式:
70 mM Tris, pH 8.0, with 150 mM sodium chloride, 20% Glycerol, and 10 µM PLP
有效期:
365
纯度:
≥70% (estimated by SDS-PAGE)
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