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CXCL9 (74-103) (human) (trifluoroacetate salt)
品牌：Cayman
货号：38849-1 mg 规格：1 mg 目录价：￥686
货号：38849-10 mg 规格：10 mg 目录价：￥5488
货号：38849-5 mg 规格：5 mg 目录价：￥3094
产品详情
产品名称:
CXCL9 (74-103) (human) (trifluoroacetate salt)
别名:
Chemokine (C-X-C motif) Ligand 9 (74-103)|MIG30|Monokine Induced by Interferon-γ (74-103)
产品描述:
Chemokine (C-X-C motif) ligand 9 (CXCL9) (74-103) is a C-terminal fragment of mature CXCL9.{66677} It binds to the glycosaminoglycan heparin in a cell-free assay (Kd = 3.1 nM).{66679} CXCL9 (74-103) inhibits the binding of CXCL8 or CXCL11 to heparin, as well as chemokine (C-C motif) ligand 2 (CCL2) binding to heparan sulfate, in a concentration-dependent manner.{66677} Unlike full-length CXCL9, CXCL9 (74-103) does not increase intracellular calcium levels in CHO cells expressing human CXC receptor 3 (CXCR3). CXCL9 (74-103) reduces the cytopathogenic effect of respiratory syncytial virus (RSV) in HeLa cells, herpes simplex virus 1 (HSV-1) in human embryonic lung (HEL) cells, and dengue virus serotype 2 in HMEC-1 cells (EC50s = 23, 15, and 11 µM, respectively).{66679} It inhibits CXCL8 (1-77)- or monosodium urate-induced neutrophil extravasation to the tibiofemoral articulation in mouse models of acute inflammation or gout, respectively, when administered at a dose of 100 µg/animal.{66677} CXCL9 (74-103) increases survival and decreases liver neutrophil infiltration and necrosis in a mouse model of liver injury induced by acetaminophen (Item No. 10024).{66678} Intravenous administration of CXCL9 (74-103) (100 µl of a 1 mg/ml solution) decreases bronchoalveolar lavage fluid (BALF) neutrophil infiltration and IL-1β levels, but does not reduce lung bacterial burden, in a mouse model of K. pneumoniae-induced pneumonia.{66680}
保存温度:
-20
运输温度:
-20
预期分子量:
3661.4
产品形式:
A solid
有效期:
1460
纯度:
≥98%
分子式:
C158H295N59O40 • XCF3COOH
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