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折扣/货期| 货号：25001 | 规格：100 µg | 目录价：￥5964 |
产品详情
产品名称:
cGAS (161-522) (human recombinant)
别名:
2’3’-cGAMP Synthase|C6orf150|cGAMP Synthase|Cyclic GMP-AMP Synthase|h-cGAS|Mab-21 domain-containing protein 1|MB21D1
产品描述:
Cyclic GMP-AMP (cGAMP) synthase (cGAS) (161-522) is a truncated form of cGAS (Item No. 22810) that contains the nucleotidyltransferase and Mab21 domains.{43137} cGAS is a nucleotidyltransferase located in the cytosol that acts as a cytosolic DNA sensor to detect foreign DNA from microbial pathogens as part of the innate immune response.{22400,22401} Upon binding to cytosolic DNA, cGAS produces the cyclic dinucleotide second messenger cGAMP, which activates stimulator of interferon genes (STING), leading to activation of the type I interferon (IFN) pathway.{22400,22401,39161} In vitro, fibroblasts, macrophages, and dendritic cells isolated from cGAS knockout (cGAS-/-) mice do not produce type I IFNs following DNA transfection or DNA virus infection.{39163} Similarly, cells containing a frame-shift mutation in the cGAS locus fail to mount an immune response to HIV and other retroviruses.{39164} In vivo, cGAS-/- mice infected with herpes simplex virus 1 (HSV-1) have lower levels of IFN-α and IFN-β, shorter survival times, and higher post-mortem levels of HSV-1 in the brain.{39163}
保存温度:
-80
运输温度:
-80
产品形式:
50 mM HEPES, pH 8.0, 150 mM sodium chloride, 1 mM DTT, and 10% glycerol
有效期:
365
纯度:
≥90% estimated by SDS-PAGE
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