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折扣/货期| 货号：31834-1 mg | 规格：1 mg | 目录价：￥38358 |
| 货号：31834-100 µg | 规格：100 µg | 目录价：￥5904 |
产品详情
产品名称:
CEACAM8/CD66b (human, recombinant)
别名:
Carcinoembryonic Antigen CGM6|Carcinoembryonic Antigen-related Cell Adhesion Molecule 8|CGM6|NCA-95|Non-specific Cross-reacting Antigen NCA-95
产品描述:
CD66b, also known as carcinoembryonic antigen-related cell adhesion molecule 8 (CEACAM8), is a member of the carcinoembryonic antigen (CEA) family encoded by CEACAM8 in humans.{54502,54499} It is a single-chain glycoprotein, comprised of N-terminal immunoglobulin (Ig) variable-like (IgV) and Ig constant-like (IgC) domains, that is anchored to the cell membrane by a glycosylphosphatidylinositol (GPI) linker.{54500} CD66b is expressed exclusively in granulocytes, with neutrophil and eosinophil expression increasing under inflammatory conditions to mediate intercellular adhesion to endothelial cells, signal transduction, and cell activation.{54502,54500} The percentage of colonic CD66b+ neutrophils is increased and positively correlates with endoscopic disease severity in patients with Crohn’s disease.{54503} The percentage of CD66b+ neutrophils is also increased in gastric cancer tissues and is associated with poor prognosis.{54501} Cayman’s CEACAM8/CD66b (human, recombinant) protein can be used for binding assays. The protein consists of 296 amino acids, has a calculated molecular weight of 32.8 kDa, and a predicted N-terminus of Gln35 after signal peptide cleavage. By SDS-PAGE, under reducing conditions, the apparent molecular mass of the protein is approximately 55 to 60 kDa due to glycosylation.
保存温度:
-80
运输温度:
-80
产品形式:
Lyophilized from sterile PBS, pH 7.4
有效期:
365
纯度:
≥96% estimated by SDS-PAGE
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