Cdk2 Isoform 1 (human, recombinant)-其他重组蛋白-ELISA_抗体_蛋白_核苷酸

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Cdk2 Isoform 1 (human, recombinant)

品牌：Cayman

官网链接

说明书

折扣/货期

货号：40793-50 µg	规格：50 µg	目录价：￥4464
货号：40793-500 µg	规格：500 µg	目录价：￥29016

产品详情

产品名称:

Cdk2 Isoform 1 (human, recombinant)

别名:

Cell Division Protein Kinase 2|Cyclin-dependent Kinase 2|p33 Protein Kinase

产品描述:

Cyclin-dependent kinase 2 (Cdk2) is a serine/threonine kinase and member of the CDK family of kinases involved in cell cycle regulation.{15254,51716} It is composed of an N-terminal domain, an activation segment, also known as the T loop, and a catalytic C-terminal domain.{51716} Alternative splicing of CDK2 mRNA produces a full-length isoform or a shorter isoform that lacks exon 5, which encodes for part of the Cdk2 activation segment and contains residues that participate in interactions with cyclins.{51717} It is ubiquitously expressed and localizes to the cytoplasm or nucleus depending on the cell cycle stage.{51718,51719} Cdk2 associates with cyclin E to mediate the G1/S transition and with cyclin A during S phase progression.{15254,51716} Knockout of Cdk2 induces gametogenesis defects in mice but does not affect mitotic cell division.{51715} Protein levels of Cdk2 are increased in patients with oral squamous cell carcinoma, and overexpression of Cdk2/cyclin A or Cdk2/cyclin E is associated with poor prognosis in patients with oral cancer.{51714} Cayman’s Cdk2 Isoform 1 (human, recombinant) protein consists of 308 amino acids and has a calculated molecular weight of 35 kDa.

宿主来源:

Insect cells

保存温度:

-80

运输温度:

-80

产品形式:

Lyophilized from sterile 50 mM Tris, pH 8.0, with 100 mM sodium chloride and 10% glycerol

有效期:

365

纯度:

≥85% estimated by SDS-PAGE, ≥95% determined by SEC-HPLC