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折扣/货期| 货号：15-0049 | 规格：100 µg | 目录价：￥3900 |
产品详情
产品名称:
BRD4 Bromodomain 1, His-HA-Tagged
产品描述:
This product differs from previous lots due to the addition of an HA tag and TEV spacer between the N-terminal His tag and the bromodomain. Recombinant human BRD4 Bromodomain 1, His-HA tagged, expressed in E. coli (HUNK1, accession number O60885, amino acids 41 to 180). BRD4 is a member of the BET sub-family of bromodomain-containing proteins, which also includes BRD2, BRD3 and BRDT. BET proteins have two bromodomains and an ET domain C-terminal to the second bromodomain. BRD4 serves as a co-factor for Myc and is crucial to Myc’s role in acute myeloid leukemia. Inhibition of BRD4 binding suppresses Myc activity and leads to differentiation of AML cells and elimination of AML stem cells.
表达系统:
E. coli
保存温度:
Stable for six months at -80°C from date of receipt. For best results, aliquot and avoid freeze/thaws.
运输温度:
Dry ice.
产品形式:
Recombinant 6xHis-HA-tagged protein at 0.98 mg/mL in 20 mM Tris-HCl pH 8.0, 200 mM NaCl, 1 mM DTT, 20% glycerol.
产地:
美国
生产商:
EpiCypher
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