货号:AG-CR1-3735-M005 | 规格:5 mg | 目录价:¥720 |
货号:AG-CR1-3735-M010 | 规格:10 mg | 目录价:¥1140 |
货号:AG-CR1-3735-M050 | 规格:50 mg | 目录价:¥2280 |
产品详情
产品名称:
Boceprevir
别名:
Victrelis; EBP 520; SCH 503034
产品描述:
The antiviral agent boceprevir is a protease inhibitor that covalently and reversibly binds to the catalytic site (Ser139) of hepatitis C virus (HCV) nonstructural protein 3/4A (NS3/4A), a serine protease that is essential for viral replication (Ki = 14nM) by cleaving the virally encoded polyprotein into mature proteins like NS4A, NS4B, NS5A and NS5B. It inhibits the NS3/4A protease in an in vitro HCV replicon system with an EC50 value of 200 nM. Boceprevir has been identified as a potential inhibitor of SARS-CoV-2 responsible for COVID-19. It inhibits SARS-CoV-2 viral replication by targeting the viral main protease Mpro (IC50 = 4.13µM).
保存温度:
-20°C
运输温度:
Ambient
预期分子量:
519.7
产品形式:
solid
有效期:
Stable for at least 2 years after receipt when stored at -20°C.
产地:
瑞士
纯度:
>95% (NMR)
CAS号:
394730-60-0
分子式:
C27H45N5O5
溶解度:
Soluble in DMSO (15mg/ml), ethanol (20mg/ml) or DMF (20mg/ml).
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