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折扣/货期| 货号：SMC-617D-A390 | 规格：100 µg | 目录价：￥5770.8 |
产品详情
产品名称:
Alpha Synuclein Antibody (Aggregate-Specific): ATTO 390
别名:
Alpha Synuclein Antibody, Non-A beta component of AD amyloid Antibody, Non-A4 component of amyloid precursor Antibody, NACP Antibody, SNCA Antibody, PARK1 Antibody, PARK 1 Antibody, alphaSYN Antibody, PARK 4 antibody, PARK4 antibody, Parkinson disease familial 1 antibody, Parkinson disease (autosomal dominant, Lewy body) 4 antibody, SYN antibody
产品描述:
Mouse Anti-Mouse Alpha Synuclein Aggregate Antibody Monoclonal IgG1
反应种属:
Human | Mouse
宿主来源:
Mouse
实验应用:
WB | DB | IP | IHC | ICC-IF | ImmunoGold labelling
靶标/特异性:
Binds a 3-dimensional fibrillar epitope including AA101-120, AA61-80
同种型:
IgG1
免疫原:
Mouse alpha synuclein fibrils
免疫原种属:
Mouse
克隆性:
Monoclonal
克隆号:
2F11
纯化方式:
Protein G Purified
偶联:
ATTO 390
产品浓度:
1mg/ml
保存温度:
-20ºC
运输温度:
Blue Ice or 4ºC
存储溶液:
PBS pH 7.4, 50% glycerol, 0.09% sodium azide. *Storage buffer may change when conjugated
产地:
加拿大
功能与背景:
Alpha-Synuclein (SNCA) is expressed predominantly in the brain, where it is concentrated in presynaptic nerve terminals (1). Alpha-synuclein is highly expressed in the mitochondria of the olfactory bulb, hippocampus, striatum and thalamus (2). Functionally, it has been shown to significantly interact with tubulin (3), and may serve as a potential microtubule-associated protein. It has also been found to be essential for normal development of the cognitive functions; inactivation may lead to impaired spatial learning and working memory (4). SNCA fibrillar aggregates represent the major non A-beta component of Alzheimer’s disease amyloid plaque, and a major component of Lewy body inclusions, and Parkinson's disease. Parkinson's disease (PD) is a common neurodegenerative disorder characterized by the progressive accumulation in selected neurons of protein inclusions containing alpha-synuclein and ubiquitin (5, 6). Covered by US patent family US11,098,108B2 (7).
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