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Zin3 AM
品牌：Adipogen
货号：CDX-F0019-C100 规格：100 ug 目录价：￥3556
货号：CDX-F0019-C500 规格：500 ug 目录价：￥14196
货号：CDX-F0019-M001 规格：1 mg 目录价：￥24864
产品详情
产品名称:
Zin3 AM
别名:
FluoZin-3 AM (Registered Trademark of ThermoFisher)
产品描述:
Zin3 AM is a cell-permeable Zn2+-selective indicator (Absorption=456nm), that once it enters the cell is hydrolized by esterases to convert the bright fluorescent Zin3 (Ex/Em: ~494/516nm). Zin3 is suitable for detection of Zn2+ concentrations in the 1–100 nM range and it has shown to be very Zn2+-sensitive and Zn2+-specific. The cell permeant AM-ester is useful for detecting low intracellular Zn2+ levels and small concentration changes. Zin3 exhibits high Zn2+-binding affinity that is unperturbed by Ca2+ concentrations up to at least 1 µM (Kd (Zn2+) (in buffer): ~15nM). In addition, Zin3 exhibits a >50-fold increase in fluorescence in response to saturating levels of Zn2+. This dye is usedpredominantly for imaging applications, but has also used in cell-based microplate assays and flow cytometry protocols. The product is typically loaded into cells by adding the dissolved indicator to medium containing cells. Zinc is an important divalent cation in biological systems, influencing DNA synthesis, microtubule polymerization, gene expression, apoptosis, immune system function and the activity of enzymes such as carbonic anhydrase and matrix metalloproteinases (MMP). Zn2+ is also functionally active in synaptic transmission, and is a contributory factor in neurological disorders including epilepsy and Alzheimer’s disease.
宿主来源:
Synthetic.
保存温度:
-20°C
运输温度:
Ambient
预期分子量:
982.85
产品形式:
solid
有效期:
Stable for at least 2 years after receipt when stored at -20°C.
产地:
瑞士
纯度:
>85% (HPLC)
CAS号:
562102-46-9
分子式:
C46H44F2N2O20
溶解度:
Soluble in DMSO or methanol.
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