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折扣/货期| 货号：34818-100 mg | 规格：100 mg | 目录价：￥6062 |
| 货号：34818-25 mg | 规格：25 mg | 目录价：￥1694 |
| 货号：34818-250 mg | 规格：250 mg | 目录价：￥10108 |
| 货号：34818-50 mg | 规格：50 mg | 目录价：￥3220 |
产品详情
产品名称:
Val-Cit-PAB-OH
别名:
Valine-Citrulline-p-Aminobenzylcarbamate|VC-PAB
产品描述:
Val-Cit-PAB-OH is a peptide linker molecule used in the synthesis of drug conjugates.{45295,45296,58751,58752,58753} It is cleaved by cathepsin B, a protease highly expressed in cancer cells, which confers specificity of the drug conjugates to cancer cells.{45296} Val-Cit-PAB-OH has been used in the synthesis of antibody-drug conjugates (ADCs) containing the tubulin polymerization inhibitors KGP05 or monomethyl auristatin D (MMAD), as well as α-galactosylceramide or folic acid conjugates that target peptide antigens to natural killer T cells or exportin 1 (CRM1) inhibitors to cancer cells, respectively.{45295,58751,58752,58753} It has also been used as a precursor in the synthesis of Mc-Val-Cit-PABC-PNP (Item No. 23881).{45295}
保存温度:
-20
运输温度:
-20
预期分子量:
379.5
产品形式:
A solid
有效期:
1460
纯度:
≥98%
CAS号:
159857-79-1
分子式:
C18H29N5O4
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