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折扣/货期| 货号：20488 | 规格：200 µg | 目录价：￥2142 |
产品详情
产品名称:
Ubiquitin (human, recombinant; His-tagged)
产品描述:
Ubiquitin is a regulatory protein encoded by three gene classes in humans, which code for fusion proteins between ubiquitin and zinc-finger proteins, ribosomal proteins, or ubiquitin repeats that are cleaved by esterases to release monomeric ubiquitin.{17707,17708} It is ubiquitously expressed and highly conserved among eukaryotic species. Ubiquitin is conjugated to misfolded, abnormal, short-lived, or foreign proteins by ubiquitin-conjugating enzymes (E2) and substrate-specific ubiquitin ligases (E3) to target them for degradation by the 26S proteasome or lysosome.{17707,26608} It is also conjugated to proteins to modify cell signaling through regulation of protein-protein interactions, activity, or subcellular localization.{26608} Dysregulation of ubiquitination has been implicated in the pathogenesis of neurodegenerative diseases, including Parkinson’s and Alzheimer’s diseases.{58819} Cayman’s Ubiquitin (human, recombinant; His-tagged) protein can be used as a substrate for enzyme activity assays, as well as for ELISA and Western blot (WB) applications.
保存温度:
-80
运输温度:
-80
产品形式:
50 mM Tris, pH 7.5, 150 mM sodium chloride, containing 5% glycerol
有效期:
730
纯度:
≥95% (estimated by SDS-PAGE)
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