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TRAF5 Monoclonal Antibody (Clone 55A219)
品牌：Cayman
货号：10873 规格：1 ea 目录价：￥6246
产品详情
产品名称:
TRAF5 Monoclonal Antibody (Clone 55A219)
产品描述:
Tumor necrosis factor (TNF)-induced signaling is mediated through association of TNF receptor (TNFR) with adaptor proteins, such as TNF receptor-associated factors (TRAFs). TRAFs form a family of cytoplasmic adapter proteins that mediate signal transduction from many members of the TNF-receptor superfamily (e.g., RANK, CD30, CD40, etc.) and the interleukin-1 receptor. The carboxy-terminal region of TRAFs is required for self-association and interaction with receptor cytoplasmic domains following ligand-induced oligomerization. Recent molecular cloning studies have led to identification of seven TRAFs (TRAF1-TRAF7).{19431,18761,19383,19384,19385} Human TRAF5 is a 557-amino acid protein. TRAF5 is implicated in NF-kB and c-Jun NH(2)-terminal kinase/stress-activated protein kinase activation by members of the TNF receptor superfamily, including CD27, CD30, CD40, and lymphotoxin-β receptor. Targeted disruption of TRAF5 gene causes defects in CD40-CD27 mediated lymphocyte activation.{19385}
宿主来源:
Mouse
实验应用:
WB
免疫原:
fusion protein corresponding to amino acids 77-186 of human TRAF5
克隆号:
55A219
保存温度:
-20
运输温度:
-20
产品形式:
100 µg of protein G-purified IgG in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide
有效期:
180
来源:
Animal/Mouse
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