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TIP60 (human, recombinant)

品牌：Cayman

官网链接

说明书

折扣/货期

货号：10783

规格：100 µg

目录价：￥6902

产品详情

产品名称:

TIP60 (human, recombinant)

别名:

产品描述:

TIP60 is a member of the MYST family of lysine acetyl transferases. It has been shown to acetylate histones, p53, and the Ataxia Telangiectasia Mutant (ATM) protein kinase.{20520} As a component of the TIP60-p400 complex, TIP60 acetylates transcription repressors in order to inhibit gene transcription.{20521} In complexes without p400, TIP60 is part of a chromatin remodeling complex which plays an important role in double-stranded DNA break repair. Acetylation of histone γH2AX allows formation of the γH2AX repair foci, and acetylation of ATM is one of the early steps in double-stranded DNA break repair. Furthermore, TIP60 is bound by the cytoplasmic tail of β-amyloid precursor protein which drives gene transcription, apoptosis, and potentially a role in Alzheimer’s disease pathogenesis.{20522}

保存温度:

-80

运输温度:

-80

产品形式:

50 mM Tris-HCl, pH 7.5, with 300 mM sodium chloride and 10% glycerol

有效期:

180

纯度:

≥50%

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