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折扣/货期| 货号：30586 | 规格：5 U | 目录价：￥6790 |
产品详情
产品名称:
Thioredoxin Reductase 1 (rat, recombinant; aa 3-499)
别名:
NADPH-dependent Thioredoxin Reductase|TrxR1|Txnrd1
产品描述:
Thioredoxin reductase 1 (TrxR1) is an oxidoreductase encoded by the TXNRD1 gene in humans and a member of the antioxidant thioredoxin system, which is involved in the maintenance of cellular thiol redox homeostasis.{14257,52830,57136} It exists as a homodimer and contains a dimer interface domain, FAD and NADPH binding domains, an N-terminal redox catalytic site, and a C-terminal selenocysteine residue, which is essential for the catalytic activity of TrxR1.{52831,14257} TrxR1 is ubiquitously expressed, localizes to the cytoplasm, and is regulated by the antioxidant transcription factor Nrf2.{52830,52832} TrxR1 catalyzes the NADPH-dependent reduction of oxidized thioredoxin (Trx), restoring the disulfide reductase function of Trx, which regulates redox-sensitive transcription factors, such as NF-κB and p53, and has roles in apoptosis and cell signaling.{52833,57136} Genome-wide deletion of Txnrd1 is embryonic lethal in mice.{52834} Increased serum TrxR1 activity is associated with reduced progression-free survival in patients with non-small cell lung cancer (NSCLC).{52835} Cayman’s Thioredoxin Reductase 1 (rat, recombinant; aa 3-499) protein can be used for enzyme activity assay and Western blot (WB) applications.
实验应用:
Enzyme activity assay and Western blot (WB)
保存温度:
-80
运输温度:
-80
产品形式:
50 mM Tris, pH 7.4, with 800 mM sodium chloride and 10% glycerol
有效期:
365
纯度:
≥45% estimated by SDS-PAGE
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